Welcome · Reading Notes

Exploring computational pathology · multi-omics · multimodal AI to understand cancer and biological systems.

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Ye Zhang · Reading Notes

This site is a lightweight reading notebook: concise, opinionated notes on papers I read, with an emphasis on how ideas can be turned into robust analysis pipelines rather than only benchmark numbers.

Main themes Computational pathology · Multi-omics · Multimodal LLM · Foundation models
Note style Concise · Critical · Implementation-minded

Today

2026-01-09 · Bridging histology and multi-omics

Tags: Multi-omics Integration, Foundation Models · NeurIPS 2024

Skimmed a paper on aligning histology with bulk RNA-seq using a joint latent space. Noted their loss design and how they handle confounders. Wrote down a potential idea for integrating perturbation data into a similar framework.

Recent days

2026-01-08 · Thoughts on perturbation screens

Tags: Perturbation Analysis · Nature Methods 2022

Read a large-scale CRISPR perturbation study. Recorded how they model gene-gene interactions and how that might be combined with spatial information.

2026-01-07 · Revisiting nuclei segmentation benchmarks

Tags: Nuclei Segmentation, Pathology · MICCAI 2021

Compared several nuclei instance segmentation architectures. Reflected on continual learning and how to design an interactive annotation loop.

2026-01-07 · Revisiting nuclei segmentation benchmarks

Tags: Nuclei Segmentation, Pathology · MICCAI 2021

Compared several nuclei instance segmentation architectures. Reflected on continual learning and how to design an interactive annotation loop.

2026-01-07 · Revisiting nuclei segmentation benchmarks

Tags: Nuclei Segmentation, Pathology · MICCAI 2021

Compared several nuclei instance segmentation architectures. Reflected on continual learning and how to design an interactive annotation loop.

2026-01-07 · Revisiting nuclei segmentation benchmarks

Tags: Nuclei Segmentation, Pathology · MICCAI 2021

Compared several nuclei instance segmentation architectures. Reflected on continual learning and how to design an interactive annotation loop.

Multi-omics

[Paper Note] Multi-omics Integration

Category: Multi-omics · Subtopic: Integration · ICML 2023

A brief summary of the problem setting, integration strategy, and how this work connects to computational pathology and cancer subtyping...

[Paper Note] Perturbation Analysis

Category: Multi-omics · Subtopic: Perturbation-based integration · Cell 2021

Notes on a study using large-scale perturbation screens to infer gene regulatory programs and cellular responses, and how these signals can be aligned with other omics layers...

Pathology

[Paper Note] Nuclei Segmentation

Category: Pathology · Subtopic: Nuclei Segmentation · CVPR 2020

A reflection on different architectures for nuclei instance segmentation, how they handle overlapping/touching nuclei, and some ideas about continual learning and prompts...

[Paper Note] Cancer Diagnosis

Category: Pathology · Subtopic: Diagnosis · Nature Medicine 2019

Notes on models and biomarkers used for cancer diagnosis from histopathology, with comments on robustness, domain shift, and interpretability...

[Paper Note] Cancer Prognosis

Category: Pathology · Subtopic: Prognosis / Risk Stratification · Nature Cancer 2022

Summary of survival models, risk scores, and how omics + image features are combined to predict outcomes...

Multimodal & Foundation Models

[Paper Note] Foundation Models in Pathology

Category: Multimodal · Subtopic: Foundation Models · NeurIPS 2023

A note on a foundation model for histopathology images: pretraining strategy, downstream tasks, scaling behavior, and open questions for multi-omics and spatial data...

[Paper Note] Multimodal Representation Learning

Category: Multimodal · Subtopic: Cross-modal representations · ICLR 2022

Thoughts on models that jointly learn from images, text, and omics, and how such representations can support reasoning and downstream tasks...